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Article

Processivity and drug-dependence of HIV-1 protease: determinants of viral fitness in variants resistant to protease inhibitors.

AIDS (London, England) - 28 Mar 2003

Menzo Stefano, Monachetti Alessia, Balotta Claudia, Corvasce Stefano, Rusconi Stefano, Paolucci Stefania, Baldanti Fausto, Bagnarelli Patrizia, Clementi Massimo

Abstract excerpt

OBJECTIVE: To investigate the role of processivity and drug-dependence of HIV-1 protease as fitness determinants in variants resistant to protease inhibitors (PI). DESIGN AND METHODS: HIV-1 protease sequences from 32 infected subjects (27 patients who failed PI-treatments and five PI-naive controls) were evaluated using a recombinant method. The HIV-1 phenotype to seven PI was analysed together with the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12646788
DOI: 10.1097/01.aids.0000050852.71999.5f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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