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Article

HIV-1 evolution under pressure of protease inhibitors: climbing the stairs of viral fitness.

Journal of biomedical science - 1 Jan 2000

Berkhout B

Abstract excerpt

The human immunodeficiency virus (HIV-1) has evolved into a viral quasispecies with a high replication capacity or fitness. Antiretroviral drugs potently inhibit replication of the wild-type virus, but HIV-1 responds by selection of drug-resistant variants. Here we review, in brief, the evolution...

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Share to Anti-HIV Agents
Share to Drug Resistance, Microbial
Share to HIV-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Protease

Share to HIV Protease Inhibitors

Share to Protein Processing, Post-Translational

Share to Selection, Genetic

Share to Virus Replication

Source

Identifiers

PMID: 10494036
DOI: 10.1007/BF02253518

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10494036-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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