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Article

HIV-1 evolution under pressure of protease inhibitors: climbing the stairs of viral fitness.

Journal of biomedical science - 1 Jan 2000

Berkhout B

Abstract excerpt

The human immunodeficiency virus (HIV-1) has evolved into a viral quasispecies with a high replication capacity or fitness. Antiretroviral drugs potently inhibit replication of the wild-type virus, but HIV-1 responds by selection of drug-resistant variants. Here we review, in brief, the evolution of resistance to protease inhibitors that is characterized by severe fitness losses and an abundance of subsequent...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to HIV Protease Inhibitors

Share to Protein Processing, Post-Translational

Share to Selection, Genetic

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Source

Identifiers

PMID: 10494036
DOI: 10.1007/BF02253518

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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