Evolution of phenotypic drug susceptibility and viral replication capacity during long-term virologic failure of protease inhibitor therapy in human immunodeficiency virus-infected adults.

Abstract excerpt

Continued use of antiretroviral therapy despite the emergence of drug-resistant human immunodeficiency virus (HIV) has been associated with the durable maintenance of plasma HIV RNA levels below pretherapy levels. The factors that may account for this partial control of viral replication were assessed in a longitudinal observational study of 20 HIV-infected adults who remained on a stable protease inhibitor-based...

Topics

• Adult
• Biological Evolution
• CD4 Lymphocyte Count
• Drug Resistance, Viral
• Genotype
• HIV Infections
• HIV Protease Inhibitors
• HIV-1
• Humans
• Longitudinal Studies