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Article

Acquisition of multi-PI (protease inhibitor) resistance in HIV-1 in vivo and in vitro.

Current pharmaceutical design - 1 Jan 2004

Yusa Keisuke, Harada Shinji

Abstract excerpt

Protease inhibitors are effective antiviral agents which can lead to a severe decrease in HIV RNA copies in plasma of naive patients, however even successful suppression of the virus with antiretroviral agents including protease inhibitor(s) (PI(s)) generates PI-resistant HIV-1 after long term treatment. Occasionally HIV-1 acquires cross-resistance to other PIs with which the patients have not been treated....

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Source

Identifiers

PMID: 15579087
DOI: 10.2174/1381612043382477

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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