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Article

Catechol-O-methyltransferase (COMT) Val108/158 Met polymorphism does not modulate executive function in children with ADHD.

BMC medical genetics - 21 Dec 2004

Taerk Evan, Grizenko Natalie, Ben Amor Leila, Lageix Philippe, Mbekou Valentin, Deguzman Rosherie, Torkaman-Zehi Adam, Ter Stepanian Marina, Baron Chantal, Joober Ridha

Abstract excerpt

BACKGROUND: An association has been observed between the catechol-O-methyltransferase (COMT) gene, the predominant means of catecholamine catabolism within the prefrontal cortex (PFC), and neuropsychological task performance in healthy and schizophrenic adults. Since several of the cognitive func...

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Source

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Identifiers

PMID: 15613245
DOI: 10.1186/1471-2350-5-30
PMCID: PMC544598

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15613245-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Catechol-O-methyltransferase (COMT) Val108/158 Met polymorphism does not modulate executive function in children with ADHD.PMID 15613245Read ↗

No evidence of association between Catechol-O-Methyltransferase (COMT) Val158Met genotype and performance on neuropsychological tasks in children with ADHD: a case-control study.Semantic proximity Read ↗

Catechol-o-methyltransferase gene and executive function in children with ADHD.Semantic proximity Read ↗

Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls.Semantic proximity Read ↗

Variations in the catechol O-methyltransferase polymorphism and prefrontally guided behaviors in adolescents.Semantic proximity Read ↗

Catechol-O-methyltransferase polymorphisms and some implications for cognitive therapeutics.Semantic proximity Read ↗

Meta-analysis of the cognitive effects of the catechol-O-methyltransferase gene Val158/108Met polymorphism.Semantic proximity Read ↗

The divergent impact of COMT Val158Met on executive function in children with and without attention-deficit/hyperactivity disorder.Semantic proximity Read ↗

A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition.Semantic proximity Read ↗

Does adult ADHD interact with COMT val (158) met genotype to influence working memory performance?Semantic proximity Read ↗

Attention-deficit/hyperactivity disorder phenotype is influenced by a functional catechol-O-methyltransferase variant.Semantic proximity Read ↗

Effects of catechol-O-methyltransferase on normal variation in the cognitive function of children.Semantic proximity Read ↗

The methionine allele of the COMT polymorphism impairs prefrontal cognition in children and adolescents with ADHD.Semantic proximity Read ↗

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