Article
Adolescence is the starting point of sex-dichotomous COMT genetic effects.
Translational psychiatry - 30 May 2017
Sannino S, Padula M C, Managò F, Schaer M, Schneider M, Armando M, Scariati E, Sloan-Bena F, Mereu M, Pontillo M, Vicari S, Contarini G, Chiabrera C, Pagani M, Gozzi A, Eliez S, Papaleo F
Abstract excerpt
The catechol-o-methyltransferase (COMT) genetic variations produce pleiotropic behavioral/neuroanatomical effects. Some of these effects may vary among sexes. However, the developmental trajectories of COMT-by-sex interactions are unclear. Here we found that extreme COMT reduction, in both humans (22q11.2 deletion syndrome COMT Met) and mice (COMT-/-), was associated to cortical thinning only after puberty and...
Topics
- Adolescent
- Animals
- Biomarkers
- Brain
- Catechol O-Methyltransferase
- Cognition
- DiGeorge Syndrome
- Female
- Frontal Lobe
- Genetic Variation
- Genotype