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Article

Human C-reactive protein protects mice from Streptococcus pneumoniae infection without binding to pneumococcal C-polysaccharide.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2007

Suresh Madathilparambil V, Singh Sanjay K, Ferguson Donald A, Agrawal Alok

Abstract excerpt

Human C-reactive protein (CRP) protects mice from lethality after infection with virulent Streptococcus pneumoniae type 3. For CRP-mediated protection, the complement system is required; however, the role of complement activation by CRP in the protection is not defined. Based on the in vitro properties of CRP, it has been assumed that protection of mice begins with the binding of CRP to pneumococcal...

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Source

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Identifiers

PMID: 17202380
DOI: 10.4049/jimmunol.178.2.1158
PMCID: PMC3818096

Genes

CRP
APC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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