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Article

Serum Amyloid P Aids Complement-Mediated Immunity to Streptococcus pneumoniae

4 Sept 2007

Abstract excerpt

The physiological functions of the acute phase protein serum amyloid P (SAP) component are not well defined, although they are likely to be important, as no natural state of SAP deficiency has been reported. We have investigated the role of SAP for innate immunity to the important human pathogen Streptococcus pneumoniae. Using flow cytometry assays, we show that SAP binds to S. pneumoniae, increases classical...

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PMID: 17845072
DOI: 10.1371/journal.ppat.0030120

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