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Article

C-reactive protein is essential for innate resistance to pneumococcal infection.

Immunology - 1 Jul 2014

Simons J Paul, Loeffler Jutta M, Al-Shawi Raya, Ellmerich Stephan, Hutchinson Winston L, Tennent Glenys A, Petrie Aviva, Raynes John G, de Souza J Brian, Lawrence Rachel A, Read Kevin D, Pepys Mark B

Abstract excerpt

No deficiency of human C-reactive protein (CRP), or even structural polymorphism of the protein, has yet been reported so its physiological role is not known. Here we show for the first time that CRP-deficient mice are remarkably susceptible to Streptococcus pneumoniae infection and are protected...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24673624
DOI: 10.1111/imm.12266
PMCID: PMC4080957

Genes

CRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24673624-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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