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Article

Role of the property of C-reactive protein to activate the classical pathway of complement in protecting mice from pneumococcal infection.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2006

Suresh Madathilparambil V, Singh Sanjay K, Ferguson Donald A, Agrawal Alok

Abstract excerpt

C-reactive protein (CRP) is not an acute-phase protein in mice, and therefore, mice are widely used to investigate the functions of human CRP. It has been shown that CRP protects mice from pneumococcal infection, and an active complement system is required for full protection. In this study, we assessed the contribution of CRP's ability of activating the classical pathway of complement in the protection of mice...

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Identifiers

PMID: 16547275
DOI: 10.4049/jimmunol.176.7.4369
PMCID: PMC3818093

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CRP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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