Article
The G-231A polymorphism in the endothelin-A receptor gene is associated with lower aortic pressure in patients with dilated cardiomyopathy.
American journal of hypertension - 1 Jan 2007
Telgmann Ralph, Harb Bassam A, Ozcelik Cemil, Perrot Andreas, Schönfelder Jacqueline, Nonnenmacher Andreas, Brand Marcus, Schmidt-Petersen Klaus, Dietz Rainer, Kreutz Reinhold, Osterziel Karl-Josef, Paul Martin, Brand-Herrmann Stefan-Martin
Abstract excerpt
BACKGROUND: The endothelin system (ES) plays an important role in blood pressure (BP) regulation and also in the pathophysiology of idiopathic dilated cardiomyopathy (DCM). Recently, we demonstrated that a genetic polymorphism in the endothelin A (ET(A)) receptor gene was associated with survival in DCM patients. The aim of this study was to determine whether polymorphisms in the ET(A) receptor gene might be...
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