Article
Molecular analysis of the estrogen receptor alpha gene in men with coronary artery disease: association with disease status.
Clinica chimica acta; international journal of clinical chemistry - 1 May 2003
Evangelopoulos Dimitrios, Alevizaki Maria, Lekakis John, Cimponeriu Adriana, Papamichael Christos, Kominakis Antonios, Kalofoutis Anastasios, Moutsatsou Paraskevi
Abstract excerpt
BACKGROUND: The vasoprotective effects of estrogens are known to be mediated by their respective estrogen receptors (ER) alpha (ERalpha) and beta (ERbeta), which are present on the vascular wall. The amino-terminal part of the ERalpha appears to be important; genetic alterations in this region have been associated with arterial hypertension. This region has not been studied in atherosclerotic disease. In the...
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