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The Arg389Gly ??1-adrenoceptor gene polymorphism determines contractile response to catecholamines

1 Nov 2004

Abstract excerpt

OBJECTIVES: Recently, the Arg389Gly beta1-adrenoceptor (beta1AR) gene polymorphism has been detected. The Arg variant exhibited increased responsiveness to agonist-induced stimulation in vitro. Functional studies in isolated human atrial muscle strips and in-vivo studies revealed contradictory results regarding the functional relevance of this polymorphism. We sought to characterize the functional consequences of...

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Adipose Tissue and Metabolism
Neuropeptides and Animal Physiology
Receptor Mechanisms and Signaling

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PMID: 15564877
DOI: 10.1097/00008571-200411000-00001

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