The deletion genotype of the angiotensin I-converting enzyme is associated with an increased vascular reactivity in vivo and in vitro.

doi:10.1016/s0735-1097(99)00299-5

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Article

The deletion genotype of the angiotensin I-converting enzyme is associated with an increased vascular reactivity in vivo and in vitro.

Journal of the American College of Cardiology - 1 Sept 1999

Henrion D, Benessiano J, Philip I, Vuillaumier-Barrot S, Iglarz M, Plantefève G, Chatel D, Hvass U, Durand G, Desmonts J M, Amouyel P, Lévy B I

Abstract excerpt

OBJECTIVES: To define a link between the deletion genotype (DD) and vascular reactivity, we studied in vivo and in vitro phenylephrine (PE)-induced tone and the effect of angiotensin II (AII) at physiological (subthreshold) concentrations on PE-induced tone. BACKGROUND: The deletion allele (D) of the angiotensin I-converting enzyme (ACE) has been associated with a higher circulating and cellular ACE activity and...

Topics

Aged
Analysis of Variance
Dose-Response Relationship, Drug
Drug Synergism
Extracorporeal Circulation
Female
Gene Deletion
Genotype
Homozygote
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

In Vitro Techniques

Male

Mammary Arteries

Middle Aged

Monitoring, Intraoperative

Peptidyl-Dipeptidase A

Phenylephrine

Vasoconstriction

Source

Open in PubMed

Identifiers

PMID: 10483967
DOI: 10.1016/s0735-1097(99)00299-5

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