Article
TGF-beta1 gene polymorphisms in patients with end-stage heart failure.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - 1 Sept 2001
Holweg C T, Baan C C, Niesters H G, Vantrimpont P J, Mulder P G, Maat A P, Weimar W, Balk A H
Abstract excerpt
BACKGROUND: The regulatory cytokine transforming growth factor (TGF)-beta1 is thought to play a role in atherosclerotic heart disease as well as in idiopathic cardiomyopathy. The production of TGF-beta1 is genetically controlled as polymorphisms in the signaling sequence of the TGF-beta1 gene leucine(10)-->proline and arginine(25)-->proline are involved in the regulation of the protein production level. We...
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