Article
Gender-specific association between preproendothelin-1 genotype and reduction of systolic blood pressure during antihypertensive treatment--results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA).
Clinical cardiology - 1 May 2004
Hallberg P, Karlsson J, Lind L, Michaëlsson K, Kurland L, Kahan T, Malmqvist K, Ohman K P, Nyström F, Liljedahl U, Syvänen A C, Melhus H
Abstract excerpt
BACKGROUND: Studies suggest that endothelin-1 contributes to the pathogenesis of hypertension. A G5665T gene polymorphism of preproendothelin-1 has been shown to be associated with higher blood pressure in overweight patients. No study has yet determined the effect of this polymorphism on the change in blood pressure during antihypertensive treatment. HYPOTHESIS: This study aimed to determine this effect in...
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