Article
Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes.
Proceedings of the National Academy of Sciences of the United States of America - 9 Jan 2007
Butty Vincent, Roy Matt, Sabeti Pardis, Besse Whitney, Benoist Christophe, Mathis Diane
Abstract excerpt
The three members of the costimulatory receptor family, CD28, CTLA-4, and ICOS, have complementary effects on T cell activation, and their balance controls the overall outcome of immune and autoimmune responses. They are encoded in a short genomic interval, and overall activity may result from interplay between allelic variants at each locus. With multiethnic DNA panels that represent a wide spectrum of human...
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