Article
SNP haplotypes and allele frequencies show evidence for disruptive and balancing selection in the human leukocyte receptor complex.
Immunogenetics - 1 Jul 2004
Norman Paul J, Cook Mark A, Carey B Sean, Carrington Christine V F, Verity David H, Hameed Kamran, Ramdath D Dan, Chandanayingyong Dasnayanee, Leppert Mark, Stephens Henry A F, Vaughan R W
Abstract excerpt
The human leukocyte receptor complex (LRC) of Chromosome 19q13.4 encodes polymorphic and highly homologous genes that are expressed by cells of the immune system and regulate their function. There is an enormous diversity at the LRC, most particularly the variable number of killer cell immunoglobulin-like receptor (KIR) genes. KIR have been associated with several disease processes due to their interaction with...
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