Impact of population admixture on the distribution of immune response co-stimulatory genes polymorphisms in a Brazilian population.

doi:10.1016/j.humimm.2015.09.045

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Article

Impact of population admixture on the distribution of immune response co-stimulatory genes polymorphisms in a Brazilian population.

Human immunology - 1 Nov 2015

Cassiano Gustavo Capatti, Santos Eduardo José Melo, Maia Maria Helena Thomaz, Furini Adriana da Cruz, Storti-Melo Luciane Moreno, Tomaz Franciele Maira Batista, Trindade Pamella Cristina Alves, Capobianco Marcela Petrolini, Amador Marcos Antônio Trindade, Viana Giselle Maria Rachid, Póvoa Marinete Marins, Santos Sidney Emanuel Batista, Machado Ricardo Luiz Dantas

Abstract excerpt

Co-stimulatory molecules are essential in the orchestration of immune response and polymorphisms in their genes are associated with various diseases. However, in the case of variable allele frequencies among continental populations, this variation can lead to biases in genetic studies conducted in admixed populations such as those from Brazil. The aim of this study was to evaluate the influence of genomic...

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PMID: 26429313
DOI: 10.1016/j.humimm.2015.09.045

Genes

ICOS
CTLA4

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