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Article

Genetic polymorphism of the human ICOS gene.

Immunogenetics - 1 Mar 2002

Haimila Katri E, Partanen Jukka A, Holopainen Päivi M

Abstract excerpt

Inducible costimulator (ICOS) is a novel receptor belonging to the same family as CD28 and CTLA4, which regulate T-lymphocyte activation in the immune response. The genes for these molecules are located adjacent to each other on Chromosome 2q33. Many autoimmune diseases have been found to be gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11904679
DOI: 10.1007/s00251-002-0431-2

Genes

ICOS
CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11904679-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Genetic polymorphism of the human ICOS gene.PMID 11904679Read ↗

Allelic variation of the inducible costimulator (ICOS) gene: detection of polymorphisms, analysis of the promoter region, and extended haplotype estimation.Semantic proximity Read ↗

ICOS gene polymorphisms in systemic lupus erythematosus: A case-control study.Semantic proximity Read ↗

Genetic variation in ICOS regulates mRNA levels of ICOS and splicing isoforms of CTLA4.Semantic proximity Read ↗

Characterization of CD28, CTLA4, and ICOS polymorphisms in three Brazilian ethnic groups.Semantic proximity Read ↗

Genetic association of coeliac disease susceptibility to polymorphisms in the ICOS gene on chromosome 2q33.Semantic proximity Read ↗

Association of genetic variation in inducible costimulator gene with outcome of kidney transplantation.Semantic proximity Read ↗

ICOS gene haplotypes correlate with IL10 secretion and multiple sclerosis evolution.Semantic proximity Read ↗

ICOS gene polymorphisms are associated with sporadic breast cancer: a case-control study.Semantic proximity Read ↗

Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes.Semantic proximity Read ↗

Inducible T-cell costimulator (ICOS) and CD28 polymorphisms possibly play a role in the pathogenesis of chronic autoreactive urticaria.Semantic proximity Read ↗

ICOS gene polymorphisms in B-cell chronic lymphocytic leukemia in the Polish population.Semantic proximity Read ↗

Haplotypes in the CTLA4 region are associated with coeliac disease in the Irish population.Semantic proximity Read ↗

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