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Article

Temperature-sensitive defects of the GSP1gene, yeast Ran homologue, activate the Tel1-dependent pathway.

Biochemical and biophysical research communications - 9 Feb 2007

Hayashi Naoyuki, Murakami Seishi, Tsurusaki Susumu, Nagaura Zen-ichiro, Oki Masaya, Nishitani Hideo, Kobayashi Masahiko, Shimizu Hiroko, Yamamoto Ken-ichi, Nishimoto Takeharu

Abstract excerpt

RanGTPase is involved in many cellular processes. It functions in nuclear-cytosolic transport and centrosome formation. Ran also localizes to chromatin as RCC1 does, its guanine nucleotide exchange factor, but Ran's function on chromatin is not known. We found that gsp1, a temperature-sensitive mutant of GSP1, a Saccharomyces cerevisiae Ran homologue, suppressed the hydroxyurea (HU) and ultra violet (UV)...

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Source

Identifiers

PMID: 17187759
DOI: 10.1016/j.bbrc.2006.12.028

Genes

ATM
RCC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Temperature-sensitive defects of the GSP1gene, yeast Ran homologue, activate the Tel1-dependent pathway.PMID 17187759Read ↗

Putative GTPase Gtr1p genetically interacts with the RanGTPase cycle in Saccharomyces cerevisiae.Semantic proximity Read ↗

A protein required for nuclear-protein import, Mog1p, directly interacts with GTP-Gsp1p, the Saccharomyces cerevisiae ran homologue.Semantic proximity Read ↗

A RanBP1 mutation which does not visibly affect nuclear import may reveal additional functions of the ran GTPase system.Semantic proximity Read ↗

Mutations in Ran system affected telomere silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Loss of RanGEF/Pim1 activity abolishes the orchestration of Ran-mediated mitotic cellular events in S. pombe.Semantic proximity Read ↗

A Tel1/MRX-dependent checkpoint inhibits the metaphase-to-anaphase transition after UV irradiation in the absence of Mec1.Semantic proximity Read ↗

Interaction between the small GTPase Ran/Gsp1p and Ntf2p is required for nuclear transport.Semantic proximity Read ↗

Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells.Semantic proximity Read ↗

Rfc5, a replication factor C component, is required for regulation of Rad53 protein kinase in the yeast checkpoint pathway.Semantic proximity Read ↗

Plant RanGAPs are localized at the nuclear envelope in interphase and associated with microtubules in mitotic cells.Semantic proximity Read ↗

The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast.Semantic proximity Read ↗

The ATM-related Tel1 protein of Saccharomyces cerevisiae controls a checkpoint response following phleomycin treatment.Semantic proximity Read ↗

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