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Article

Putative GTPase Gtr1p genetically interacts with the RanGTPase cycle in Saccharomyces cerevisiae.

Journal of cell science - 1 Sept 1996

Nakashima N, Hayashi N, Noguchi E, Nishimoto T

Abstract excerpt

In order to identify a protein interacting with RCC1, a guanine nucleotide-exchange factor for the nuclear GTPase Ran, we isolated a series of cold-sensitive suppressors of mtr1-2, a temperature-sensitive mutant of the Saccharomyces cerevisiae RCC1 homologue. One of the isolated suppressor mutant...

Topics

Base Sequence
Cell Cycle Proteins
DNA Primers
DNA-Binding Proteins
Fungal Proteins
GTP Phosphohydrolases
Gene Deletion
Genes, Fungal
Genes, Suppressor
Guanine Nucleotide Exchange Factors
Mutation
Nuclear Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae

Temperature

ran GTP-Binding Protein

Source

Identifiers

PMID: 8886981
DOI: 10.1242/jcs.109.9.2311

Genes

RCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8886981-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Putative GTPase Gtr1p genetically interacts with the RanGTPase cycle in Saccharomyces cerevisiae.PMID 8886981Read ↗

A protein required for nuclear-protein import, Mog1p, directly interacts with GTP-Gsp1p, the Saccharomyces cerevisiae ran homologue.Semantic proximity Read ↗

Nuclear protein import, but not mRNA export, is defective in all Saccharomyces cerevisiae mutants that produce temperature-sensitive forms of the Ran GTPase homologue Gsp1p.Semantic proximity Read ↗

Temperature-sensitive defects of the GSP1gene, yeast Ran homologue, activate the Tel1-dependent pathway.Semantic proximity Read ↗

Genetic interaction of DED1 encoding a putative ATP-dependent RNA helicase with SRM1 encoding a mammalian RCC1 homolog in Saccharomyces cerevisiae.Semantic proximity Read ↗

A RanBP1 mutation which does not visibly affect nuclear import may reveal additional functions of the ran GTPase system.Semantic proximity Read ↗

Yrb2p, a Nup2p-related yeast protein, has a functional overlap with Rna1p, a yeast Ran-GTPase-activating protein.Semantic proximity Read ↗

Interaction between the small GTPase Ran/Gsp1p and Ntf2p is required for nuclear transport.Semantic proximity Read ↗

Mutations in the YRB1 gene encoding yeast ran-binding-protein-1 that impair nucleocytoplasmic transport and suppress yeast mating defects.Semantic proximity Read ↗

Mutants in a yeast Ran binding protein are defective in nuclear transport.Semantic proximity Read ↗

RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4.Semantic proximity Read ↗

The importin/karyopherin Kap114 mediates the nuclear import of TATA-binding protein.Semantic proximity Read ↗

Discovery of a splicing regulator required for cell cycle progression.Semantic proximity Read ↗

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