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Article

Loss of RanGEF/Pim1 activity abolishes the orchestration of Ran-mediated mitotic cellular events in S. pombe.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Jan 2006

Hirose Eiji, Mukai Mari, Shimada Atsushi, Nishitani Hideo, Shibata Yosaburo, Nishimoto Takeharu

Abstract excerpt

RCC1, a conserved chromosomal protein with a seven-bladed propeller is a GDP/GTP nucleotide exchange factor for RanGTPase that mediates various cellular events. We isolated 16 temperature-sensitive (ts) mutants of S. pombeRCC1-homolog, pim1+, by error-prone PCR. Five pim1(ts) mutants had a single mutation. The obtained pim1(ts) mutations and previously reported mutations were localized on similar sites in seven...

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Source

Identifiers

PMID: 16371130
DOI: 10.1111/j.1365-2443.2005.00919.x

Genes

RCC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Loss of RanGEF/Pim1 activity abolishes the orchestration of Ran-mediated mitotic cellular events in S. pombe.PMID 16371130Read ↗

A mutation in the RCC1-related protein pim1 results in nuclear envelope fragmentation in fission yeast.Semantic proximity Read ↗

The Ran GTPase system in fission yeast affects microtubules and cytokinesis in cells that are competent for nucleocytoplasmic protein transport.Semantic proximity Read ↗

A fission yeast RCC1-related protein is required for the mitosis to interphase transition.Semantic proximity Read ↗

A RanBP1 mutation which does not visibly affect nuclear import may reveal additional functions of the ran GTPase system.Semantic proximity Read ↗

Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase.Semantic proximity Read ↗

Schizosaccharomyces pombe RanGAP homolog, SpRna1, is required for centromeric silencing and chromosome segregation.Semantic proximity Read ↗

Perturbations in the spi1p GTPase cycle of Schizosaccharomyces pombe through its GTPase-activating protein and guanine nucleotide exchange factor components result in similar phenotypic consequences.Semantic proximity Read ↗

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Spi1 GTPase interacts with RCC1 to maintain interdependency of cell cycle events.Semantic proximity Read ↗

The fission yeast ran GTPase is required for microtubule integrity.Semantic proximity Read ↗

A screen for Schizosaccharomyces pombe mutants defective in rereplication identifies new alleles of rad4+, cut9+ and psf2+.Semantic proximity Read ↗

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