Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rfc5, a replication factor C component, is required for regulation of Rad53 protein kinase in the yeast checkpoint pathway.

Molecular and cellular biology - 1 Oct 1997

Sugimoto K, Ando S, Shimomura T, Matsumoto K

Abstract excerpt

The RFC5 gene encodes a small subunit of replication factor C (RFC) complex in Saccharomyces cerevisiae. We have previously shown that a temperature-sensitive (ts) rfc5-1 mutation is impaired in the S-phase checkpoint. In this report, we show that the rfc5-1 mutation is sensitive to DNA-damaging agents. RFC5 is necessary for slowing the S-phase progression in response to DNA damage. The phosphorylation of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Binding Proteins
Share to DNA Damage
Share to DNA Replication

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fungal Proteins

Share to Gene Expression Regulation, Fungal

Share to Genes, Fungal

Share to Mutation

Share to Phosphorylation

Source

Open in PubMed Open full text

Identifiers

PMID: 9315648
DOI: 10.1128/MCB.17.10.5905
PMCID: PMC232438

Genes

RFC5
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rfc5, a replication factor C component, is required for regulation of Rad53 protein kinase in the yeast checkpoint pathway.PMID 9315648Read ↗

Allele-specific interactions between the yeast RFC1 and RFC5 genes suggest a basis for RFC subunit-subunit interactions.Semantic proximity Read ↗

Functional and physical interaction between Rad24 and Rfc5 in the yeast checkpoint pathways.Semantic proximity Read ↗

Rfc5, in cooperation with rad24, controls DNA damage checkpoints throughout the cell cycle in Saccharomyces cerevisiae.Semantic proximity Read ↗

Phosphorylation of the replication protein A large subunit in the Saccharomyces cerevisiae checkpoint response.Semantic proximity Read ↗

The RFC2 gene, encoding the third-largest subunit of the replication factor C complex, is required for an S-phase checkpoint in Saccharomyces cerevisiae.Semantic proximity Read ↗

Role of the C terminus of Mec1 checkpoint kinase in its localization to sites of DNA damage.Semantic proximity Read ↗

Rad53 phosphorylation site clusters are important for Rad53 regulation and signaling.Semantic proximity Read ↗

Protein kinase C controls activation of the DNA integrity checkpoint.Semantic proximity Read ↗

Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation.Semantic proximity Read ↗

Replication factor C3 of Schizosaccharomyces pombe, a small subunit of replication factor C complex, plays a role in both replication and damage checkpoints.Semantic proximity Read ↗

Characterization of the activation domain of the Rad53 checkpoint kinase.Semantic proximity Read ↗

Rad53 kinase activation-independent replication checkpoint function of the N-terminal forkhead-associated (FHA1) domain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.