Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast.

Proceedings of the National Academy of Sciences of the United States of America - 24 Dec 1996

Brush G S, Morrow D M, Hieter P, Kelly T J

Abstract excerpt

Replication protein A (RPA) is a highly conserved single-stranded DNA-binding protein, required for cellular DNA replication, repair, and recombination. In human cells, RPA is phosphorylated during the S and G2 phases of the cell cycle and also in response to ionizing or ultraviolet radiation. Sa...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Binding Proteins
Share to DNA Repair
Share to Fungal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Fungal

Share to Genotype

Share to Phosphorylation

Share to Point Mutation

Share to Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 8986766
DOI: 10.1073/pnas.93.26.15075
PMCID: PMC26358

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-8986766-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast.PMID 8986766Read ↗

Evidence of meiotic crossover control in Saccharomyces cerevisiae through Mec1-mediated phosphorylation of replication protein A.Semantic proximity Read ↗

Phosphorylation of the replication protein A large subunit in the Saccharomyces cerevisiae checkpoint response.Semantic proximity Read ↗

Functions of human replication protein A (RPA): From DNA replication to DNA damage and stress responsesSemantic proximity Read ↗

In vitro analysis of the role of replication protein A (RPA) and RPA phosphorylation in ATR-mediated checkpoint signaling.Semantic proximity Read ↗

The meiosis-specific protein kinase Ime2 directs phosphorylation of replication protein A.Semantic proximity Read ↗

DNA Damage and Replication Stress CheckpointsSemantic proximity Read ↗

A Tel1/MRX-dependent checkpoint inhibits the metaphase-to-anaphase transition after UV irradiation in the absence of Mec1.Semantic proximity Read ↗

Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress.Semantic proximity Read ↗

The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation.Semantic proximity Read ↗

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.Semantic proximity Read ↗

Role of the C terminus of Mec1 checkpoint kinase in its localization to sites of DNA damage.Semantic proximity Read ↗

Proteins in the nutrient-sensing and DNA damage checkpoint pathways cooperate to restrain mitotic progression following DNA damage.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.