Article
CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population.
BMC medicine - 21 Dec 2006
Enaw James O Ebot, Zhu Huiping, Yang Wei, Lu Wei, Shaw Gary M, Lammer Edward J, Finnell Richard H
Abstract excerpt
BACKGROUND: Neural tube defects (NTDs) are among the most common of all human congenital defects. Over the last two decades, accumulating evidence has made it clear that periconceptional intake of folic acid can significantly reduce the risk of NTD affected pregnancies. This beneficial effect may be related to the ability of folates to donate methyl groups for critical physiological reactions. Choline is an...
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