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Article

118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects.

BMC medical genetics - 3 Jun 2009

Shaw Gary M, Lu Wei, Zhu Huiping, Yang Wei, Briggs Farren B S, Carmichael Suzan L, Barcellos Lisa F, Lammer Edward J, Finnell Richard H

Abstract excerpt

BACKGROUND: Folic acid taken in early pregnancy reduces risks for delivering offspring with several congenital anomalies. The mechanism by which folic acid reduces risk is unknown. Investigations into genetic variation that influences transport and metabolism of folate will help fill this data gap. We focused on 118 SNPs involved in folate transport and metabolism. METHODS: Using data from a California...

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Source

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Identifiers

PMID: 19493349
DOI: 10.1186/1471-2350-10-49
PMCID: PMC2700092

Genes

MTRR
TYMS
BHMT
CBS
MTHFD1
MTHFD2
MTHFR
MTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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