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Article

Nicotinamide N-methyl transferase (NNMT) gene polymorphisms and risk for spina bifida.

Birth defects research. Part A, Clinical and molecular teratology - 1 Oct 2008

Lu Wei, Zhu Huiping, Wen Shu, Yang Wei, Shaw Gary M, Lammer Edward J, Finnell Richard H

Abstract excerpt

BACKGROUND: Moderate hyperhomocysteinemia is a known risk factor for NTDs in a variety of experimental model systems and is believed to be important in humans as well. The enzyme nicotinamide N-methyl transferase (NNMT) was identified in a genome-wide linkage scan as being an important regulator of homocysteine homeostasis in a Spanish population, making it an interesting candidate gene for NTDs. METHODS: We...

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Identifiers

PMID: 18553462
DOI: 10.1002/bdra.20474
PMCID: PMC2630518

Genes

NNMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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