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Article

Polymorphisms located in the region containing BHMT and BHMT2 genes as maternal protective factors for orofacial clefts.

European journal of oral sciences - 1 Aug 2010

Mostowska Adrianna, Hozyasz Kamil K, Biedziak Barbara, Misiak Jan, Jagodzinski Pawel P

Abstract excerpt

Nonsyndromic cleft lip with or without cleft palate (NCL/P) is one of the most common craniofacial malformations; however, its aetiology is still unclear. Because the effects of maternal nutrition on fetal development are well known, we decided to pursue the question of whether polymorphic variants of genes encoding enzymes involved in choline metabolism might be associated with the maternal risk of having a baby...

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Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Share to Chromosomes, Human, Pair 5

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20662904
DOI: 10.1111/j.1600-0722.2010.00757.x

Genes

BHMT2
NCL
BHMT
PEMT
CHDH
CHKA
DMGDH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Polymorphisms located in the region containing BHMT and BHMT2 genes as maternal protective factors for orofacial clefts.PMID 20662904Read ↗

Associations of folate and choline metabolism gene polymorphisms with orofacial clefts.Semantic proximity Read ↗

BHMT gene polymorphisms as risk factors for cleft lip and cleft palate in a Chinese population.Semantic proximity Read ↗

Sequence variation in folate pathway genes and risks of human cleft lip with or without cleft palate.Semantic proximity Read ↗

Evidence of interaction between genes in the folate/homocysteine metabolic pathway in controlling risk of non-syndromic oral cleft.Semantic proximity Read ↗

Maternal choline concentrations during pregnancy and choline-related genetic variants as risk factors for neural tube defects.Semantic proximity Read ↗

Non-syndromic cleft lip with or without cleft palate in Asian populations: Association analysis on three gene polymorphisms of the folate pathway.Semantic proximity Read ↗

Two SNPs rs1801133 and rs1801394 in folate pathway are associated with the risk of nonsyndromic cleft lip with or without cleft palateSemantic proximity Read ↗

SNPs in folate pathway are associated with the risk of nonsyndromic cleft lip with or without cleft palate, a meta-analysis.Semantic proximity Read ↗

Folate pathway and nonsyndromic cleft lip and palate.Semantic proximity Read ↗

CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population.Semantic proximity Read ↗

Maternal MTR genotype contributes to the risk of non-syndromic cleft lip and palate in the Polish population.Semantic proximity Read ↗

Are the betaine-homocysteine methyltransferase (BHMT and BHMT2) genes risk factors for spina bifida and orofacial clefts?Semantic proximity Read ↗

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