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Article

Maternal vitamin use, genetic variation of infant methylenetetrahydrofolate reductase, and risk for spina bifida.

American journal of epidemiology - 1 Jul 1998

Shaw G M, Rozen R, Finnell R H, Wasserman C R, Lammer E J

Abstract excerpt

Maternal periconceptional use of vitamin supplements containing folic acid substantially reduces the risk of neural tube defects (NTDs) in the offspring. The mechanism underlying this reduction in risk is unknown. Several recent studies have reported an association between homozygosity for a variant form (the C677T genotype) of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and risk for NTDs in...

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Identifiers

PMID: 9663401
DOI: 10.1093/oxfordjournals.aje.a009555

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Maternal vitamin use, genetic variation of infant methylenetetrahydrofolate reductase, and risk for spina bifida.PMID 9663401Read ↗

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