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Article

Maternal choline concentrations during pregnancy and choline-related genetic variants as risk factors for neural tube defects.

The American journal of clinical nutrition - 1 Oct 2014

Mills James L, Fan Ruzong, Brody Lawrence C, Liu Aiyi, Ueland Per M, Wang Yifan, Kirke Peadar N, Shane Barry, Molloy Anne M

Abstract excerpt

BACKGROUND: Low maternal choline intake and blood concentration may be risk factors for having a child with a neural tube defect (NTD); however, the data are inconsistent. This is an important question to resolve because choline, if taken periconceptionally, might add to the protective effect currently being achieved by folic acid. OBJECTIVE: We examined the relation between NTDs, choline status, and genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25240073
DOI: 10.3945/ajcn.113.079319
PMCID: PMC4163794

Genes

PEMT

Variants

rs7946

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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