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Article

The NAT1 C1095A polymorphism, maternal multivitamin use and smoking, and the risk of spina bifida.

Birth defects research. Part A, Clinical and molecular teratology - 1 Jul 2005

Jensen Liselotte E, Hoess Katy, Whitehead Alexander S, Mitchell Laura E

Abstract excerpt

BACKGROUND: The risk of having a child with a neural tube defect (NTD) can be reduced by maternal, periconceptional supplementation with folic acid, but the underlying folate-dependent protective mechanism remains unclear. N-acetyltransferase 1 is involved in acetylation of aromatic and heterocyc...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15959877
DOI: 10.1002/bdra.20143

Genes

NAT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15959877-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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The NAT1 C1095A polymorphism, maternal multivitamin use and smoking, and the risk of spina bifida.PMID 15959877Read ↗

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Spina bifida as a multifactorial birth defect: Risk factors and genetic underpinningsSemantic proximity Read ↗

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Altered folate metabolism and disposition in mothers affected by a spina bifida pregnancy: influence of 677c --> t methylenetetrahydrofolate reductase and 2756a --> g methionine synthase genotypes.Semantic proximity Read ↗

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Paternal transmission of MTHFD1 G1958A variant predisposes to neural tube defects in the offspring.Semantic proximity Read ↗

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