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Article

The NAT1 C1095A polymorphism, maternal multivitamin use and smoking, and the risk of spina bifida.

Birth defects research. Part A, Clinical and molecular teratology - 1 Jul 2005

Jensen Liselotte E, Hoess Katy, Whitehead Alexander S, Mitchell Laura E

Abstract excerpt

BACKGROUND: The risk of having a child with a neural tube defect (NTD) can be reduced by maternal, periconceptional supplementation with folic acid, but the underlying folate-dependent protective mechanism remains unclear. N-acetyltransferase 1 is involved in acetylation of aromatic and heterocyclic amines and the catabolism of folates. Hence, functional polymorphisms in NAT1, the gene encoding...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15959877
DOI: 10.1002/bdra.20143

Genes

NAT1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The NAT1 C1095A polymorphism, maternal multivitamin use and smoking, and the risk of spina bifida.PMID 15959877Read ↗

Loss of function polymorphisms in NAT1 protect against spina bifida.Semantic proximity Read ↗

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Maternal periconceptional vitamin use, genetic variation of infant reduced folate carrier (A80G), and risk of spina bifida.Semantic proximity Read ↗

Periconceptional multivitamin intake during early pregnancy, genetic variation of acetyl-N-transferase 1 (NAT1), and risk for orofacial clefts.Semantic proximity Read ↗

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Spina bifida as a multifactorial birth defect: Risk factors and genetic underpinningsSemantic proximity Read ↗

Nicotinamide N-methyl transferase (NNMT) gene polymorphisms and risk for spina bifida.Semantic proximity Read ↗

Altered folate metabolism and disposition in mothers affected by a spina bifida pregnancy: influence of 677c --> t methylenetetrahydrofolate reductase and 2756a --> g methionine synthase genotypes.Semantic proximity Read ↗

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Paternal transmission of MTHFD1 G1958A variant predisposes to neural tube defects in the offspring.Semantic proximity Read ↗

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