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Article

Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences.

The Journal of experimental medicine - 25 Dec 2006

Yang Shu Yuan, Fugmann Sebastian D, Schatz David G

Abstract excerpt

It is thought that gene conversion (GCV) and somatic hypermutation (SHM) of immunoglobulin (Ig) genes occur in two steps: the generation of uracils in DNA by activation-induced cytidine deaminase, followed by their subsequent repair by various DNA repair pathways to generate sequence-diversified products. It is not known how either of the two steps is targeted specifically to Ig loci. Because of the tight link...

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Identifiers

PMID: 17178919
DOI: 10.1084/jem.20061835
PMCID: PMC2118177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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