Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Complex regulation of somatic hypermutation by cis-acting sequences in the endogenous IgH gene in hybridoma cells.

Proceedings of the National Academy of Sciences of the United States of America - 16 Aug 2005

Ronai Diana, Iglesias-Ussel Maria Dolores, Fan Manxia, Shulman Marc J, Scharff Matthew D

Abstract excerpt

To create high-affinity antibodies, B cells target a high rate of somatic hypermutation (SHM) to the Ig variable-region genes that encode the antigen-binding site. This mutational process requires transcription and is triggered by activation-induced cytidine deaminase (AID), which converts deoxycytidine to deoxyuridine. Mistargeting of AID to non-Ig genes is thought to result in the malignant transformation of B...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hybridomas

Share to Immunoglobulin Heavy Chains

Share to Introns

Share to Mutation

Share to Somatic Hypermutation, Immunoglobulin

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 16087866
DOI: 10.1073/pnas.0505449102
PMCID: PMC1188009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Complex regulation of somatic hypermutation by cis-acting sequences in the endogenous IgH gene in hybridoma cells.PMID 16087866Read ↗

Somatic hypermutation of the AID transgene in B and non-B cellsSemantic proximity Read ↗

Targeting of somatic hypermutation by immunoglobulin enhancer and enhancer-like sequences.Semantic proximity Read ↗

Somatic hypermutation mechanisms during lymphomagenesis and transformation.Semantic proximity Read ↗

Attracting AID to targets of somatic hypermutation.Semantic proximity Read ↗

Balancing AID and DNA repair during somatic hypermutation.Semantic proximity Read ↗

Why does somatic hypermutation by AID require transcription of its target genes?Semantic proximity Read ↗

Identification of core DNA elements that target somatic hypermutation.Semantic proximity Read ↗

Immunoglobulin somatic hypermutation.Semantic proximity Read ↗

Biased dA/dT somatic hypermutation as regulated by the heavy chain intronic iEmu enhancer and 3'Ealpha enhancers in human lymphoblastoid B cells.Semantic proximity Read ↗

Somatic hypermutation of immunoglobulin and non-immunoglobulin genes.Semantic proximity Read ↗

Molecular mechanisms of antibody somatic hypermutation.Semantic proximity Read ↗

Human antibody heavy chain variable region exon interacts with 3’ regulatory region to form a stable somatic hypermutation centerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.