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Article

Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP.

The EMBO journal - 20 Feb 2008

Harzheim Dagmar, Pfeiffer K Holger, Fabritz Larissa, Kremmer Elisabeth, Buch Thorsten, Waisman Ari, Kirchhof Paulus, Kaupp U Benjamin, Seifert Reinhard

Abstract excerpt

Important targets for cAMP signalling in the heart are hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels that underlie the depolarizing 'pacemaker' current, I(f). We studied the role of I(f) in mice, in which binding of cAMP to HCN4 channels was abolished by a single amino-ac...

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Share to Cyclic AMP
Share to Cyclic Nucleotide-Gated Cation Channels
Share to Embryonic Development

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Rate

Share to Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels

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Share to Myocytes, Cardiac

Source

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Identifiers

PMID: 18219271
DOI: 10.1038/emboj.2008.3
PMCID: PMC2262033

Genes

HCN4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18219271-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP.PMID 18219271Read ↗

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