Article
PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents.
Neuron - 27 Mar 2003
Zhang Hailin, Craciun Liviu C, Mirshahi Tooraj, Rohács Tibor, Lopes Coeli M B, Jin Taihao, Logothetis Diomedes E
Abstract excerpt
KCNQ channels belong to a family of potassium ion channels with crucial roles in physiology and disease. Heteromers of KCNQ2/3 subunits constitute the neuronal M channels. Inhibition of M currents, by pathways that stimulate phospholipase C activity, controls excitability throughout the nervous system. Here we show that a common feature of all KCNQ channels is their activation by the signaling membrane...
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