Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LXR alpha transactivates mouse organic solute transporter alpha and beta via IR-1 elements shared with FXR.

Pharmaceutical research - 1 Feb 2007

Okuwaki Masae, Takada Tappei, Iwayanagi Yuki, Koh Saori, Kariya Yoshiaki, Fujii Hiroshi, Suzuki Hiroshi

Abstract excerpt

PURPOSE: Recently identified organic solute transporter (Ost) alpha and beta are located on the basolateral membrane of enterocytes and may be responsible for the intestinal absorption of many substrates including bile acids. In the present study, the mechanism governing the transcriptional regulation of their expression was investigated. METHODS AND RESULTS: To clarify the transcriptional regulation of Osts,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5' Flanking Region
Share to Electrophoretic Mobility Shift Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatocyte Nuclear Factor 4

Share to Liver X Receptors

Share to Luciferases

Share to Orphan Nuclear Receptors

Share to Receptors, Cytoplasmic and Nuclear

Share to Repetitive Sequences, Nucleic Acid

Source

Identifiers

PMID: 17177110
DOI: 10.1007/s11095-006-9163-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LXR alpha transactivates mouse organic solute transporter alpha and beta via IR-1 elements shared with FXR.PMID 17177110Read ↗

Expression of organic cation transporter 1 (OCT1): unique patterns of indirect regulation by nuclear receptors and hepatospecific gene regulationSemantic proximity Read ↗

Mechanistic insights into isoform-dependent and species-specific regulation of bile salt export pump by farnesoid X receptor.Semantic proximity Read ↗

The Interface between Cell Signaling Pathways and Pregnane X ReceptorSemantic proximity Read ↗

Liver X receptor β increases aquaporin 2 protein level via a posttranscriptional mechanism in renal collecting ducts.Semantic proximity Read ↗

Minireview: liver X receptor beta: emerging roles in physiology and diseases.Semantic proximity Read ↗

Transcriptional regulation of hepatobiliary transport systems in health and disease: Implications for a rationale approach to the treatment of intrahepatic cholestasisSemantic proximity Read ↗

Genome‐wide tissue‐specific farnesoid X receptor binding in mouse liver and intestine†Semantic proximity Read ↗

Transcriptional modulations by RXR agonists are only partially subordinated to PPARalpha signaling and attest additional, organ-specific, molecular cross-talks.Semantic proximity Read ↗

Involvement of ESE-3, epithelial-specific ETS factor family member 3, in transactivation of the ABCB1 gene via pregnane X receptor in intestine-derived LS180 cells but not in liver-derived HepG2 cells.Semantic proximity Read ↗

The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis.Semantic proximity Read ↗

Interleukin-1beta suppresses retinoid transactivation of two hepatic transporter genes involved in bile formation.Semantic proximity Read ↗

SHP-dependent and -independent induction of peroxisome proliferator-activated receptor-γ by the bile acid sensor farnesoid X receptor counter-regulates the pro-inflammatory phenotype of liver myofibroblasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.