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Article

Mechanistic insights into isoform-dependent and species-specific regulation of bile salt export pump by farnesoid X receptor.

Journal of lipid research - 1 Nov 2013

Song Xiulong, Chen Yuan, Valanejad Leila, Kaimal Rajani, Yan Bingfang, Stoner Matthew, Deng Ruitang

Abstract excerpt

Expression of bile salt export pump (BSEP) is regulated by the bile acid/farnesoid X receptor (FXR) signaling pathway. Two FXR isoforms, FXRα1 and FXRα2, are predominantly expressed in human liver. We previously showed that human BSEP was isoform-dependently regulated by FXR and diminished with altered expression of FXRα1 and FXRα2 in patients with hepatocellular carcinoma. In this study, we demonstrate that...

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Identifiers

PMID: 24002920
DOI: 10.1194/jlr.M038323
PMCID: PMC3793607

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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