Article
Liver X receptor β increases aquaporin 2 protein level via a posttranscriptional mechanism in renal collecting ducts.
American journal of physiology. Renal physiology - 1 Apr 2017
Su Wen, Huang Shi-Zheng, Gao Min, Kong Xiao-Mu, Gustafsson Jan-Åke, Xu Su-Juan, Wang Bing, Zheng Feng, Chen Li-Hong, Wang Nan-Ping, Guan You-Fei, Zhang Xiao-Yan
Abstract excerpt
Liver X receptors (LXRs) including LXRα and LXRβ are nuclear receptor transcription factors and play an important role in lipid and glucose metabolism. It has been previously reported that mice lacking LXRβ but not LXRα develop a severe urine concentrating defect, likely via a central mechanism. Here we provide evidence that LXRβ regulates water homeostasis through increasing aquaporin 2 (AQP2) protein levels in...
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