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Article

Interleukin-1beta suppresses retinoid transactivation of two hepatic transporter genes involved in bile formation.

The Journal of biological chemistry - 24 Mar 2000

Denson L A, Auld K L, Schiek D S, McClure M H, Mangelsdorf D J, Karpen S J

Abstract excerpt

Cytokines have been implicated in the pathogenesis of inflammatory cholestasis. This is due to transcriptional down-regulation of hepatic transporters including the Na(+)/bile acid cotransporter, ntcp, and the multispecific organic anion exporter, mrp2. We have recently shown that ntcp suppression by lipopolysaccharide in vivo is caused by down-regulation of transactivators including the previously...

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PMID: 10722729
DOI: 10.1074/jbc.275.12.8835

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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