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Article

The Interface between Cell Signaling Pathways and Pregnane X Receptor

22 Nov 2021

Abstract excerpt

Highly expressed in the enterohepatic system, pregnane X receptor (PXR, NR1I2) is a well-characterized nuclear receptor (NR) that regulates the expression of genes in the liver and intestines that encode key drug metabolizing enzymes and drug transporter proteins in mammals. The net effect of PXR activation is to increase metabolism and clear drugs and xenobiotics from the body, producing a protective effect and...

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PMID: 34831484
DOI: 10.3390/cells10113262

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