Article
Transcriptional modulations by RXR agonists are only partially subordinated to PPARalpha signaling and attest additional, organ-specific, molecular cross-talks.
Gene expression - 1 Jan 2005
Martin Pascal G P, Lasserre Frédéric, Calleja Cécile, Van Es Armelle, Roulet Alain, Concordet Didier, Cantiello Michela, Barnouin Romain, Gauthier Béatrice, Pineau Thierry
Abstract excerpt
Nuclear hormone receptors (NR) are important transcriptional regulators of numerous genes involved in diverse pathophysiological and therapeutic functions. Following ligand activation, class II NR share the ability to heterodimerize with the retinoid X receptor (RXR). It is established that RXR activators, rexinoids, transactivate several peroxisome proliferator-activated receptor alpha (PPARalpha) target genes...
Topics
- Animals
- Apolipoproteins
- Bexarotene
- Blotting, Northern
- Cell Nucleus
- Cluster Analysis
- Dimerization
- Fenofibrate
- Gene Expression Regulation
- Genotype