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Article

Effect of tryptophan hydroxylase-2 gene variants on amygdalar and hippocampal volumes.

Brain research - 17 May 2010

Inoue Hideyuki, Yamasue Hidenori, Tochigi Mamoru, Takei Kunio, Suga Motomu, Abe Osamu, Yamada Haruyasu, Rogers Mark A, Aoki Shigeki, Sasaki Tsukasa, Kasai Kiyoto

Abstract excerpt

Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the synthesis of serotonin (5-HT). Genetic variations in human TPH2, a newly identified isoform of TPH, have been shown to impact on enzymatic activity of TPH and to be associated with emotion-related personality traits and mood/anxiety disorders. Identification of an intermediate phenotype that bridges the relationship between genes and behavior may be...

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Source

Identifiers

PMID: 20331984
DOI: 10.1016/j.brainres.2010.03.057

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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