A nonfunctional sequence converted to a signal for glycophosphatidylinositol membrane anchor attachment.

doi:10.1083/jcb.115.2.329

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Article

A nonfunctional sequence converted to a signal for glycophosphatidylinositol membrane anchor attachment.

The Journal of cell biology - 1 Oct 1991

Moran P, Caras I W

Abstract excerpt

The COOH terminus of decay-accelerating factor (DAF) contains a signal that directs glycophosphatidylinositol (GPI) membrane anchor attachment in a process involving concerted proteolytic removal of 28 COOH-terminal residues. At least two elements are required for anchor addition: a COOH-terminal hydrophobic domain and a cleavage/attachment site located NH2-terminal to it, requiring a small amino acid as the...

Topics

Amino Acid Sequence
CD55 Antigens
Cell Line
Cell Membrane
Enzyme-Linked Immunosorbent Assay
Glycolipids
Glycosylphosphatidylinositols
Growth Hormone
Humans
Membrane Proteins
Microscopy, Fluorescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Peptide Fragments

Phosphatidylinositols

Precipitin Tests

Protein Sorting Signals

Receptors, LDL

Source

Open in PubMed Open full text

Identifiers

PMID: 1717483
DOI: 10.1083/jcb.115.2.329
PMCID: PMC2289147

Genes

GPI
LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1717483-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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