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Article

Activation of the PDGF β Receptor by a Persistent Artificial Signal Peptide.

Journal of molecular biology - 15 Oct 2021

Petti Lisa M, Koleske Benjamin N, DiMaio Daniel

Abstract excerpt

Most eukaryotic transmembrane and secreted proteins contain N-terminal signal peptides that mediate insertion of the nascent translation products into the membrane of the endoplasmic reticulum. After membrane insertion, signal peptides typically are cleaved from the mature protein and degraded. Here, we tested whether a small hydrophobic protein selected for growth promoting activity in mammalian cells retained...

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Identifiers

PMID: 34474086
DOI: 10.1016/j.jmb.2021.167223
PMCID: PMC8530902

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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