Article
Carboxyl terminus structural requirements for glycosyl-phosphatidylinositol anchor addition to cell surface proteins.
Journal of cell science - 1 Jul 1993
Beghdadi-Rais C, Schreyer M, Rousseaux M, Borel P, Eisenberg R J, Cohen G H, Bron C, Fasel N
Abstract excerpt
Glycosyl phosphatidylinositol (GPI)-anchored proteins contain in their COOH-terminal region a peptide segment that is thought to direct glycolipid addition. This signal has been shown to require a pair of small amino acids positioned 10-12 residues upstream of an hydrophobic C-terminal domain. We analysed the contribution of the region separating the anchor acceptor site and the C-terminal hydrophobic segment by...
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