Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biosynthesis of surfactant protein C (SP-C). Sorting of SP-C proprotein involves homomeric association via a signal anchor domain.

The Journal of biological chemistry - 31 May 2002

Wang Wen-Jing, Russo Scott J, Mulugeta Surafel, Beers Michael F

Abstract excerpt

Rat surfactant protein C (SP-C) is synthesized as a 194-amino acid propeptide (SP-C-(1-194)) that is directed to the distal secretory pathway and proteolytically processed as an integral membrane protein to yield its mature form. We had shown previously that trafficking of proSP-C is mediated both by a signal anchor domain contained within the mature SP-C sequence and by a targeting domain in the NH(2)-flanking...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cross-Linking Reagents
Share to Cysteine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytoplasm

Share to Cytosol

Share to Dimerization

Share to Immunoblotting

Share to Proteolipids

Share to Pulmonary Surfactants

Source

Identifiers

PMID: 11907042
DOI: 10.1074/jbc.M201537200

Genes

EEA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biosynthesis of surfactant protein C (SP-C). Sorting of SP-C proprotein involves homomeric association via a signal anchor domain.PMID 11907042Read ↗

Deletion of exon 4 from human surfactant protein C results in aggresome formation and generation of a dominant negative.Semantic proximity Read ↗

The juxtamembrane lysine and arginine residues of surfactant protein C precursor influence palmitoylation via effects on trafficking.Semantic proximity Read ↗

Divergent Pathways of Surfactant Protein C Maturation for Disease-Associated IsoformsSemantic proximity Read ↗

Surfactant protein C biosynthesis and its emerging role in conformational lung disease.Semantic proximity Read ↗

Nonspecific interstitial pneumonia, alveolar proteinosis, and abnormal proprotein trafficking resulting from a spontaneous mutation in the surfactant protein C gene.Semantic proximity Read ↗

Methylprednisolone pulse treatment improves ProSP-C trafficking in twins with SFTPC mutation: An isoform story?Semantic proximity Read ↗

Divergent pathways of surfactant protein C maturation for disease-associated isoforms.Semantic proximity Read ↗

Processing of surfactant protein C requires a type II transmembrane topology directed by juxtamembrane positively charged residues.Semantic proximity Read ↗

A nonaggregating surfactant protein C mutant is misdirected to early endosomes and disrupts phospholipid recycling.Semantic proximity Read ↗

A non-BRICHOS surfactant protein c mutation disrupts epithelial cell function and intercellular signaling.Semantic proximity Read ↗

Surfactant protein C: its unique properties and emerging immunomodulatory role in the lung.Semantic proximity Read ↗

Overexpression of surfactant protein-C mature peptide causes neonatal lethality in transgenic mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.