Article
The C-terminus of glycosylphosphatidylinositol-specific phospholipase D is essential for biological activity.
Biochimica et biophysica acta - 4 Feb 1997
Stadelmann B, Bütikofer P, König A, Brodbeck U
Abstract excerpt
Glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) (EC 3.1.4.50) from mammalian serum is a 115 kDa glycoprotein consisting of 816 amino acids. We found that C-terminal deletions of only two to five amino acids reduced GPI-PLD enzymatic activity by roughly 70% as compared to wild-type protein. C-terminal deletions of more than five amino acids resulted in a complete loss of GPI-PLD enzymatic activity....
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