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Article

Proteasome and thiol involvement in quality control of glycosylphosphatidylinositol anchor addition.

The Biochemical journal - 15 May 1998

Wilbourn B, Nesbeth D N, Wainwright L J, Field M C

Abstract excerpt

Improperly processed secretory proteins are degraded by a hydrolytic system that is associated with the endoplasmic reticulum (ER) and appears to involve re-export of lumenal proteins into the cytoplasm for ultimate degradation by the proteasome. The chimaeric protein hGHDAF28, which contains a crippled glycosylphosphatidylinositol (GPI) C-terminal signal peptide, is degraded by a pathway highly similar to that...

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Identifiers

PMID: 9576858
DOI: 10.1042/bj3320111
PMCID: PMC1219458

Genes

GPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Proteasome and thiol involvement in quality control of glycosylphosphatidylinositol anchor addition.PMID 9576858Read ↗

Quality Control of GPI-Anchored ProteinsSemantic proximity Read ↗

Post-ER degradation of misfolded GPI-anchored proteins is linked with microautophagySemantic proximity Read ↗

Active site determination of Gpi8p, a caspase-related enzyme required for glycosylphosphatidylinositol anchor addition to proteins.Semantic proximity Read ↗

GPI-anchored Gas1 protein regulates cytosolic proteostasis in yeastSemantic proximity Read ↗

Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein.Semantic proximity Read ↗

Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.Semantic proximity Read ↗

Hrd1-dependent Degradation of the Unassembled PIGK Subunit of the GPI Transamidase Complex.Semantic proximity Read ↗

MCD4 encodes a conserved endoplasmic reticulum membrane protein essential for glycosylphosphatidylinositol anchor synthesis in yeast.Semantic proximity Read ↗

Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3.Semantic proximity Read ↗

Truncation of the caspase-related subunit (Gpi8p) of Saccharomyces cerevisiae GPI transamidase: dimerization revealed.Semantic proximity Read ↗

Pathogenic mutations located in the hydrophobic core of the prion protein interfere with folding and attachment of the glycosylphosphatidylinositol anchor.Semantic proximity Read ↗

Evidence for coupled biogenesis of yeast Gap1 permease and sphingolipids: essential role in transport activity and normal control by ubiquitination.Semantic proximity Read ↗

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