Article
Functional analysis of T-cell mutants defective in the biosynthesis of glycosylphosphatidylinositol anchor. Relative importance of glycosylphosphatidylinositol anchor versus N-linked glycosylation in T-cell activation.
The Journal of biological chemistry - 5 Dec 1991
Thomas L J, DeGasperi R, Sugiyama E, Chang H M, Beck P J, Orlean P, Urakaze M, Kamitani T, Sambrook J F, Warren C D
Abstract excerpt
The glycosylphosphatidylinositol (GPI) anchor, potentially capable of generating a number of second messengers, such as diacylglycerol, phosphatidic acid, and inositol phosphate glycan, has been postulated to be involved in signal transduction in various cell types, including T-cells. We have identified a panel of T-cell hybridoma mutants that are defective at various steps of GPI anchor biosynthesis. Since they...
Topics
- Antigens, CD
- Antigens, Differentiation, T-Lymphocyte
- CD3 Complex
- Carbohydrate Sequence
- Cell Line
- Flow Cytometry
- Genes, Fungal
- Glycolipids
- Glycosylation
- Glycosylphosphatidylinositols